Acetylcholinesterase in goldfish muscles. Studies on some substrates and inhibitors
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چکیده
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Some new carbacylamidophosphates as inhibitors of acetylcholinesterase and butyrylcholinesterase.
The differences in the inhibition activity of organophosphorus agents are a manifestation of different molecular properties of the inhibitors involved in the interaction with the active site of enzyme. We were interested in comparing the inhibition potency of four known synthesized carbacylamidophosphates with the general formula RC(O)NHP(O)Cl2, constituting organophosphorus compounds, where R ...
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Background and objectives: The cholinergic deficit correlates with the severity of Alzheimer’s disease. The cholinergic function can be improved by AChE inhibitors blocking this key enzyme in the breakdown of acetylcholine. Based on traditional medicine, during two last decades the use of herbal medicinal substances in dementia therapy has been studied. The fruit extract of <em...
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A striking characteristic of this decade in biochemistry is the introduction of selective blocking agents as tools for research. A maior area of application has been in studies on nucleic acid and protein synthesis 1. As findings in diverse areas are correlated, the details of the selective nature of these toxic substances become known, adding to their value. The use of selective blocking agent...
متن کاملAcetylcholinesterase Inhibitors: Pharmacology and Toxicology
Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. The enzyme inactivation, induced by various inhibitors, leads to acetylcholine accumulation, hyperstimulation of nicotinic and muscarinic receptors, and disrupted neurotransmission. H...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1959
ISSN: 0306-3283
DOI: 10.1042/bj0720210